Established in the 1750s, the St. Regis Mission Catholic Church has been an iconic fixture at the confluence of the St. Lawrence and St. Regis rivers for centuries. The St. Regis Mission Catholic Church was established by French Catholic priests, but it wasn’t until 1795 that the beautiful stone building was built, making it one of the oldest buildings in the region. Oral history recounts that the church was built on traditional Mohawk ceremonial grounds. The location was also important due to its direct river access and was the site of many historic events, such as battles in the War of 1812. 

Both the Catholic faith and Mohawk traditions are represented within the St. Regis Mission Catholic Church, which occasionally offers services and hymns in the Mohawk language. The church itself features unique Mohawk artwork and visuals, which meld with traditional Catholic design elements and religious fixtures. While the majority of people who worship at St. Regis Mission Catholic Church are Mohawk, visitors are welcome to come visit or worship at the historic church.